Omega-3 Fatty Acids for Depression in Multiple Sclerosis: A Randomized Pilot Study.

ABSTRACT:

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Multiple sclerosis is the most common chronic disabling disease in the central nervous system in young to middle aged adults. Depression is common in multiple sclerosis (MS) affecting between 50–60% of patients. Pilot studies in unipolar depression report an improvement in depression when omega-3 fatty acids are given with antidepressants. The objective of this study was to investigate whether omega-3 fatty acid supplementation, as an augmentation therapy, improves treatment-resistant major depressive disorder (MDD) in people with MS. We performed a randomized, double-blind, placebo-controlled pilot study of omega-3 fatty acids at six grams per day over three months. The primary outcome was a 50% or greater improvement on the Montgomery-Asberg Depression Rating Scale (MA

SUBMITTER: Shinto L 

PROVIDER: S-EPMC4723316 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature