Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?

ABSTRACT:

Background

Polymorphisms in SNCA, MAPT and LRRK2 genes have recently been confirmed as risk factors for Parkinson's disease (PD), although with small individual attributable risk. Here we investigated the association of PD with interactions between variants of these genes.

Methods

As part of a previous study of PD susceptibility genes 119 SNCA, MAPT, and LRRK2 haplotype tagging single nucleotide polymorphisms (SNPs) and two variable number tandem repeats (VNTRs) were genotyped in 1098 PD cases from the upper Midwest, USA and 1098 matched controls. Twenty-six of these SNPs were selected for SNP-SNP (or SNP-VNTR or VNTR-VNTR) interaction analysis (256 interaction pairs). Case-control analyses were performed to study association of pairwise SNP interactions with PD susceptibili

SUBMITTER: Biernacka JM 

PROVIDER: S-EPMC4723425 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature