Identification of Microorganisms by High Resolution Tandem Mass Spectrometry with Accurate Statistical Significance.

ABSTRACT: Correct and rapid identification of microorganisms is the key to the success of many important applications in health and safety, including, but not limited to, infection treatment, food safety, and biodefense. With the advance of mass spectrometry (MS) technology, the speed of identification can be greatly improved. However, the increasing number of microbes sequenced is challenging correct microbial identification because of the large number of choices present. To properly disentangle candidate microbes, one needs to go beyond apparent morphology or simple 'fingerprinting'; to correctly prioritize the candidate microbes, one needs to have accurate statistical significance in microbial identification. We meet these challenges by using peptidome profiles of microbes to better separate them

SUBMITTER: Alves G 

PROVIDER: S-EPMC4723618 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature