Hypoxia/lncRNA-AK123072/EGFR pathway induced metastasis and invasion in gastric cancer.

ABSTRACT:

Objective

To investigate the role of long noncoding RNAs (lncRNAs) in hypoxia-induced gastric cancer (GC) metastasis and invasion.

Methods

We investigated the differentially expressed lncRNAs resulting from hypoxia-induced GC and normoxia conditions using microarrays and validated our results through real-time quantitative polymerase chain reaction. The role of the targeting lncRNA was further detected by in vivo and in vitro assays.

Results

We found an lncRNA, AK123072, which was up-regulated by hypoxia. AK123072 was frequently up-regulated in GC samples and promoted GC migration and invasion in vivo and in vitro. Furthermore, AK123072 could mediate the metastasis of hypoxia-induced GC cells. Next, we identified EGFR, which was a metastasis-related gene regulated by

SUBMITTER: Yang Z 

PROVIDER: S-EPMC4723753 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature