The association of TGFB1 genetic polymorphisms with high myopia: a systematic review and meta-analysis.

ABSTRACT:

Objective

The TGFB1 gene is among the most studied genes in high myopia due to its role in scleral remodeling. But reported findings of association on TGFB1 and high myopia are inconsistent. This present study is to evaluate the association of TGFB1 polymorphisms and high myopia.

Methods

A comprehensive literature search was conducted on studies published up to April 5, 2015. Summary odds ratios (ORs) and 95% confidence intervals were analyzed. Heterogeneity across studies was evaluated by Cochran Q statistic test and the I(2) index. Sensitivity analyses were conducted by the approach of one-study remove to assess the influence of single study on the combined effect.

Results

Eight studies were included in this study for meta-analysis. Rs1982073 was associated with hig

SUBMITTER: Meng B 

PROVIDER: S-EPMC4723797 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature