Cytochrome P450 2C9 (CYP2C9) polymorphisms in Chinese Li population.

ABSTRACT:

Background

The frequencies of Cytochrome P450 2C9 (CYP2C9) genotypes were various between populations. The aim of this study was to investigate the frequencies of the major variants of the CYP2C9 in Chinese Li minority populations.

Methods

The promoter, exons and surrounding introns, and 3'-untranslated region of the CYP2C9 gene was detected by DNA sequencing to investigate in 100 unrelated healthy Chinese Li subjects. The protein function prediction was used the online tools: Sorting Intolerant From Tolerant (SIFT) and Phenotyping Version 2 (PolyPhen-2). The comparison of CYP2C9 allele frequencies in different populations were analyzed by Chi-square (χ(2)) test. Linkage disequilibrium (LD) analysis was performed using Haploview software.

Results

We identified 17 diff

SUBMITTER: Ding Y 

PROVIDER: S-EPMC4723878 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature