A tagging ALOX5AP polymorphism and risk of ischemic stroke in a northeastern Chinese Han population.

ABSTRACT:

Objective

5-lipoxygenase-activating protein gene (ALOX5AP) has been recognized as a susceptibility gene for stroke. In this work, we explored the association of 6 ALOX5AP SNPs with cerebral infarction (CI) in a northeastern Chinese Han population, using a case-control design.

Methods

A group of patients with cerebral infarction were randomly chosen as case group in northeastern Chinese Han population. Another comparative group of individuals without stroke were chosen as the control group. By utilizing TaqMan probe based real-time fluorescent PCR and DNA sequencing method, this study focused on 6 SNPs of ALOX5AP gene and analyzed the association with the hereditary susceptibility of cerebral infarction.

Results

We found that, the rs9579646 G allele frequency was signi

SUBMITTER: Qu Z 

PROVIDER: S-EPMC4723920 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature