Association between genetic polymorphism in NFKB1 and NFKBIA and coronary artery disease in a Chinese Han population.

ABSTRACT:

Objectives

Prior studies have demonstrated NF-κB plays an important role in the development and progression of inflammatory diseases. The aim of this study was to investigate whether promoter polymorphisms in NFKB1 and NFKBIA gene are associated with coronary artery disease (CAD) in a Chinese Han population.

Methods

A total of 1140 Han CAD patients and 1156 Han control subjects were genotyped for 4 single-nucleotide polymorphisms (SNPs) in the promoter region of NFKBIA gene (rs3138053, rs2233406, rs2233409) and NFKB1 gene (-94 ins/del ATTG, rs28362491) by using the TaqMan SNP genotyping assays, and then NFKBIA haplotype blocks were reconstructed according to our genotyping data.

Results

For total, men, and women, the distribution of genotypes, alleles of rs3138053, rs

SUBMITTER: Lai H 

PROVIDER: S-EPMC4723942 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature