Utility of Nontraditional Risk Markers in Atherosclerotic Cardiovascular Disease Risk Assessment.

ABSTRACT:

Background

The improvement in discrimination gained by adding nontraditional cardiovascular risk markers cited in the 2013 American College of Cardiology/American Heart Association cholesterol guidelines to the atherosclerotic cardiovascular disease (ASCVD) risk estimator (pooled cohort equation [PCE]) is untested.

Objectives

This study assessed the predictive accuracy and improvement in reclassification gained by the addition of the coronary artery calcium (CAC) score, the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) levels, and family history (FH) of ASCVD to the PCE in participants of MESA (Multi-Ethnic Study of Atherosclerosis).

Methods

The PCE was calibrated (cPCE) and used for this analysis. The Cox proportional hazards survival model,

SUBMITTER: Yeboah J 

PROVIDER: S-EPMC4724058 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature