Classification and characterization of human endogenous retroviruses; mosaic forms are common.

ABSTRACT:

Background

Human endogenous retroviruses (HERVs) represent the inheritance of ancient germ-line cell infections by exogenous retroviruses and the subsequent transmission of the integrated proviruses to the descendants. ERVs have the same internal structure as exogenous retroviruses. While no replication-competent HERVs have been recognized, some retain up to three of four intact ORFs. HERVs have been classified before, with varying scope and depth, notably in the RepBase/RepeatMasker system. However, existing classifications are bewildering. There is a need for a systematic, unifying and simple classification. We strived for a classification which is traceable to previous classifications and which encompasses HERV variation within a limited number of clades.

Results

The huma

SUBMITTER: Vargiu L 

PROVIDER: S-EPMC4724089 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature