Cognitive remission: a novel objective for the treatment of major depression?

ABSTRACT:

Background

Cognitive dysfunction in major depressive disorder (MDD) encompasses several domains, including but not limited to executive function, verbal memory, and attention. Furthermore, cognitive dysfunction is a frequent residual manifestation in depression and may persist during the remitted phase. Cognitive deficits may also impede functional recovery, including workforce performance, in patients with MDD. The overarching aims of this opinion article are to critically evaluate the effects of available antidepressants as well as novel therapeutic targets on neurocognitive dysfunction in MDD.

Discussion

Conventional antidepressant drugs mitigate cognitive dysfunction in some people with MDD. However, a significant proportion of MDD patients continue to experience signifi

SUBMITTER: Bortolato B 

PROVIDER: S-EPMC4724131 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature