Association of common variants identified by recent genome-wide association studies with obesity in Chinese children: a case-control study.

ABSTRACT:

Background

Large-scale genome-wide association studies have identified multiple genetic variants that are associated with elevated body mass index (BMI) or the risk of obesity in Caucasian or Asian populations. We examined whether these variants are individually associated with obesity in Chinese children, and also assessed their cumulative effects and predictive value for obesity risk in Chinese children.

Methods

We genotyped 40 single nucleotide polymorphisms (SNPs) and conducted association analyses for 32/40 SNPs with an estimated minor allele frequency >1% in 2 030 unrelated Chinese children, including 607 normal-weight, 718 overweight, and 705 obese individuals from two cross-sectional study groups. Logistic regression and linear regression under the additive model wer

SUBMITTER: Wang HJ 

PROVIDER: S-EPMC4724138 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature