Apolipoprotein E gene polymorphism and risk of type 2 diabetes and cardiovascular disease.

ABSTRACT:

Background

Lipoprotein-related mechanisms have been associated with damage to the cardiovascular system in diabetic patients. Apolipoprotein E gene which affects the clearance of lipoproteins and consequently the lipid profile in our body is one of the most studied candidate genes and recently has been reported to be associated with T2DM and CAD. In this work, we studied the association of apoE gene polymorphism with T2DM and CVD and its effect on plasma lipids profile.

Methods

Our study was conducted on 284 subjects categorized into 100 patients with T2DM, 100 patients with T2DM complicated with CVD and 84 normal control subjects. ApoE gene polymorphism was genotyped by real-time PCR using TaqMan(®) SNP Genotyping Assay.

Results

ApoE E3/E3 genotype was the most commo

SUBMITTER: El-Lebedy D 

PROVIDER: S-EPMC4724147 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature