Alterations of oxidative phosphorylation in meningiomas and peripheral nerve sheath tumors.

ABSTRACT:

Background

Changes in the mode of aerobic energy production are observed in many solid tumors, though the kinds of changes differ among tumor types. We investigated mitochondrial energy metabolism in meningiomas and peripheral nerve sheath tumors, taking into consideration the histologic heterogeneity of these tumors.

Methods

Oxidative phosphorylation (OXPHOS) complexes and porin (a marker for mitochondrial mass) were analyzed by immunohistochemical staining of meningiomas (n = 76) and peripheral nerve sheath tumors (schwannomas: n = 10; neurofibromas: n = 4). The enzymatic activities of OXPHOS complexes and citrate synthase were determined by spectrophotometric measurement. Western blot analysis of OXPHOS complexes, porin, and mitochondrial transcription factor A was perfor

SUBMITTER: Feichtinger RG 

PROVIDER: S-EPMC4724172 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature