Influenza vaccine response in adults exposed to perfluorooctanoate and perfluorooctanesulfonate.

ABSTRACT: Supported by several epidemiological studies and a large number of animal studies, certain polyfluorinated alkyl acids are believed to be immunotoxic, affecting particularly humoral immunity. Our aim was to investigate the relationship between the antibody response following vaccination with an inactivated trivalent influenza vaccine and circulating levels of perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS). The study population consisted of 411 adults living in the mid-Ohio region of Ohio and West Virginia where public drinking water had been inadvertently contaminated with PFOA. They participated in a larger cross-sectional study in 2005/2006 and were followed up in 2010, by which time serum levels of PFOA had been substantially reduced but were still well above those found

SUBMITTER: Looker C 

PROVIDER: S-EPMC4724206 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature