GBA Variants are associated with a distinct pattern of cognitive deficits in Parkinson's disease.

ABSTRACT:

Background

Loss-of-function mutations in the GBA gene are associated with more severe cognitive impairment in PD, but the nature of these deficits is not well understood and whether common GBA polymorphisms influence cognitive performance in PD is not yet known.

Methods

We screened the GBA coding region for mutations and the E326K polymorphism in 1,369 PD patients enrolled at eight sites from the PD Cognitive Genetics Consortium. Participants underwent assessments of learning and memory (Hopkins Verbal Learning Test-Revised), working memory/executive function (Letter-Number Sequencing Test and Trail Making Test A and B), language processing (semantic and phonemic verbal fluency), visuospatial abilities (Benton Judgment of Line Orientation), and global cognitive function (MoC

SUBMITTER: Mata IF 

PROVIDER: S-EPMC4724255 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature