Muscle fiber type specific activation of the slow myosin heavy chain 2 promoter by a non-canonical E-box.

ABSTRACT: Different mechanisms control skeletal muscle fiber type gene expression at specific times in vertebrate development. Embryonic myogenesis leading to formation of primary muscle fibers in avian species is largely directed by myoblast cell commitment to the formation of diverse fiber types. In contrast, development of different secondary fiber types during fetal myogenesis is partly determined by neural influences. In both primary and secondary chicken muscle fibers, differential expression of the slow myosin heavy chain 2 (MyHC2) gene distinguishes fast from fast/slow muscle fibers. This study focused on the transcriptional regulation of the slow MyHC2 gene in primary myotubes formed from distinct fast/slow and fast myogenic cell lineages. Promoter deletion analyses identified a discrete 86

SUBMITTER: Weimer K 

PROVIDER: S-EPMC4724272 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature