Regional white matter development in very preterm infants: perinatal predictors and early developmental outcomes.

ABSTRACT:

Background

Preterm infants are at risk for white matter (WM) injury and adverse neurodevelopmental outcomes.

Methods

Serial diffusion tensor magnetic resonance imaging data were obtained from very preterm infants (N = 78) born <30 wk gestation imaged up to four times from 26-42 wk postmenstrual age. Slopes were calculated for fractional anisotropy (FA) and mean diffusivity (MD) within regions of interest for infants with ≥2 scans (N = 50). Sixty-five children underwent neurodevelopmental testing at 2 y of age.

Results

FA slope for the posterior limb of the internal capsule was greater than other regions. The anterior limb of the internal capsule (ALIC), corpus callosum, and optic radiations demonstrated greater FA slope with increasing gestational age. Infants with pa

SUBMITTER: Rogers CE 

PROVIDER: S-EPMC4724306 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature