Baseline genetic associations in the Parkinson's Progression Markers Initiative (PPMI).

ABSTRACT:

Background

The Parkinson's Progression Marker Initiative is an international multicenter study whose main goal is investigating markers for Parkinson's disease (PD) progression as part of a path to a treatment for the disease. This manuscript describes the baseline genetic architecture of this study, providing not only a catalog of disease-linked variants and mutations, but also quantitative measures with which to adjust for population structure.

Methods

Three hundred eighty-three newly diagnosed typical PD cases, 65 atypical PD and 178 healthy controls, from the Parkinson's Progression Marker Initiative study have been genotyped on the NeuroX or Immunochip arrays. These data are freely available to all researchers interested in pursuing PD research within the Parkinson's Pr

SUBMITTER: Nalls MA 

PROVIDER: S-EPMC4724309 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature