Incidental Cerebral Microbleeds and Cerebral Blood Flow in Elderly Individuals.

ABSTRACT:

Importance

Cerebral microbleeds (CMBs) are collections of blood breakdown products that are a common incidental finding in magnetic resonance imaging of elderly individuals. Cerebral microbleeds are associated with cognitive deficits, but the mechanism is unclear. Studies show that individuals with CMBs related to symptomatic cerebral amyloid angiopathy have abnormal vascular reactivity and cerebral blood flow (CBF), but, to our knowledge, abnormalities in cerebral blood flow have not been reported for healthy individuals with incidental CMBs.

Objective

To evaluate the association of incidental CMBs with resting-state CBF, cerebral metabolism, cerebrovascular disease, β-amyloid (Aβ), and cognition.

Design, setting, and participants

A cross-sectional study of 55 cognit

SUBMITTER: Gregg NM 

PROVIDER: S-EPMC4724412 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature