Rotating magnetic field induced oscillation of magnetic particles for in vivo mechanical destruction of malignant glioma.

ABSTRACT: Magnetic particles that can be precisely controlled under a magnetic field and transduce energy from the applied field open the way for innovative cancer treatment. Although these particles represent an area of active development for drug delivery and magnetic hyperthermia, the in vivo anti-tumor effect under a low-frequency magnetic field using magnetic particles has not yet been demonstrated. To-date, induced cancer cell death via the oscillation of nanoparticles under a low-frequency magnetic field has only been observed in vitro. In this report, we demonstrate the successful use of spin-vortex, disk-shaped permalloy magnetic particles in a low-frequency, rotating magnetic field for the in vitro and in vivo destruction of glioma cells. The internalized nanomagnets align themselves to th

SUBMITTER: Cheng Y 

PROVIDER: S-EPMC4724455 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature