Sex-dependence of anxiety-like behavior in cannabinoid receptor 1 (Cnr1) knockout mice.

ABSTRACT: Epidemiological data suggest women are at increased risk for developing anxiety and depression, although the mechanisms for this sex/gender difference remain incompletely understood. Pre-clinical studies have begun to investigate sex-dependent emotional learning and behavior in rodents, particularly as it relates to psychopathology; however, information about how gonadal hormones interact with the central nervous system is limited. We observe greater anxiety-like behavior in male mice with global knockout of the cannabinoid 1 receptor (Cnr1) compared to male, wild-type controls as measured by percent open arm entries on an elevated plus maze test. A similar increase in anxiety-like behavior, however, is not observed when comparing female Cnr1 knockouts to female wild-type subjects. Althoug

SUBMITTER: Bowers ME 

PROVIDER: S-EPMC4724469 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature