Mechanistic Study on Electronic Excitation Dissociation of the Cellobiose-Na(+) Complex.

ABSTRACT: The recent development of electron activated dissociation (ExD) techniques has opened the door for high-throughput, detailed glycan structural elucidation. Among them, ExD methods employing higher-energy electrons offer several advantages over low-energy electron capture dissociation (ECD), owing to their applicability towards chromophore-labeled glycans and singly charged ions, and ability to provide more extensive structural information. However, a lack of understanding of these processes has hindered rational optimization of the experimental conditions for more efficient fragmentation as well as the development of informatics tools for interpretation of the complex glycan ExD spectra. Here, cellobiose-Na(+) was used as the model system to investigate the fragmentation behavior of metal-

SUBMITTER: Huang Y 

PROVIDER: S-EPMC4724539 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature