Influence of Catechol-O-methyltransferase on Executive Functioning Longitudinally After Early Childhood Traumatic Brain Injury: Preliminary Findings.

ABSTRACT:

Objective

To elucidate the association of a functional catechol-O-methyltransferase (COMT) genotype (rs4680) with recovery of executive functions up to 18 months after early childhood traumatic brain injury (TBI) compared with an orthopedic injury (OI) group.

Setting

Outpatient.

Participants

A total of 134 children with a moderate to severe TBI (n = 63) or OI (n = 71) between the ages of 3 and 6 years who were followed 18 months postinjury.

Design

Case-comparison, longitudinal cohort

Main measures

: The Behavior Rating Inventory of Executive Function, developmental NEuroPSYchological Assessment (NEPSY) of Verbal Fluency, and a modified Stroop Test for young children (Shape School).

Results

The low-activity COMT enzyme genotype (AA) was associated

SUBMITTER: Kurowski BG 

PROVIDER: S-EPMC4724555 | biostudies-literature | 2016 May-Jun

REPOSITORIES: biostudies-literature