Outer retinal changes following acute optic neuritis.

ABSTRACT:

Background

Retinal nerve fiber and ganglion cell+inner plexiform (GCIP) layer thinning following multiple sclerosis-related acute optic neuritis (AON) is well described. However, whether AON results in changes in the inner nuclear (INL), outer plexiform (OPL), outer nuclear (ONL) and/or photoreceptor segment (PS) layers remains undetermined.

Objectives

The objective of this paper is to determine if INL+OPL and/or ONL+PS changes occur following AON.

Methods

Thirty-three AON patients underwent serial optical coherence tomography (OCT) and visual function testing (mean follow-up: 25 months). Longitudinal changes in retinal layer thickness were analyzed using mixed-effects linear regression.

Results

Four months following AON, the mean decrease in GCIP thickness rel

SUBMITTER: Al-Louzi OA 

PROVIDER: S-EPMC4724567 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature