Bisphenol A sulfonation is impaired in metabolic and liver disease.

ABSTRACT:

Background

Bisphenol A (BPA) is a widely used industrial chemical and suspected endocrine disruptor to which humans are ubiquitously exposed. The liver metabolizes and facilitates BPA excretion through glucuronidation and sulfonation. The sulfotransferase enzymes contributing to BPA sulfonation (detected in human and rodents) is poorly understood.

Objectives

To determine the impact of metabolic and liver disease on BPA sulfonation in human and mouse livers.

Methods

The capacity for BPA sulfonation was determined in human liver samples that were categorized into different stages of metabolic and liver disease (including obesity, diabetes, steatosis, and cirrhosis) and in livers from ob/ob mice.

Results

In human liver tissues, BPA sulfonation was substantially lo

SUBMITTER: Yalcin EB 

PROVIDER: S-EPMC4724572 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature