Innate immunity and hepatocarcinoma: Can toll-like receptors open the door to oncogenesis?

ABSTRACT: Hepatocarcinoma (HCC) is a highly prevalent cancer worldwide and its inflammatory background was established long ago. Recent studies have shown that innate immunity is closely related to the HCC carcinogenesis. An effective innate immunity response relies on the toll-like receptors (TLR) found in several different liver cells which, through different ligands and many signaling pathways can elicit, not only a pro-inflammatory but also an oncogenic or anti-oncogenic response. Our aim was to study the role of TLRs in the liver oncogenesis and as a consequence their value as potential therapeutic targets. We performed a systematic review of PubMed searching for original articles studying the relationship between HCC and TLRs until March 2015. TLR2 appears to be a fundamental stress-sensor as

SUBMITTER: Lopes JA 

PROVIDER: S-EPMC4724579 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature