Physical Modeling of Dynamic Coupling between Chromosomal Loci.

ABSTRACT: The motion of chromosomal DNA is essential to many biological processes, including segregation, transcriptional regulation, recombination, and packaging. Physical understanding of these processes would be dramatically enhanced through predictive, quantitative modeling of chromosome dynamics of multiple loci. Using a polymer dynamics framework, we develop a prediction for the correlation in the velocities of two loci on a single chromosome or otherwise connected by chromatin. These predictions reveal that the signature of correlated motion between two loci can be identified by varying the lag time between locus position measurements. In general, this theory predicts that as the lag time interval increases, the dual-loci dynamic behavior transitions from being completely uncorrelated to beha

SUBMITTER: Lampo TJ 

PROVIDER: S-EPMC4724634 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature