Response of Vitamin D Concentration to Vitamin D3 Administration in Older Adults without Sun Exposure: A Randomized Double-Blind Trial.

ABSTRACT:

Objectives

To determine the dose-response relationship between 25-hydroxyvitamin D (25(OH)D) and supplemental vitamin D3 in elderly nursing home residents.

Design

Randomized double-blind investigation.

Setting

Nursing home.

Participants

Of 81 women (n=51) and men (n=30) (mean age 87.4±8) enrolled, 72 completed the study.

Intervention

Sixteen weeks of oral vitamin D3 at 800, 2,000, or 4,000 IU/d or 50,000 IU/wk.

Measurements

The main outcome was 25(OH)D concentrations (tandem mass spectrometry) after 16 weeks. Free 25(OH)D and intact parathyroid hormone (iPTH) were also analyzed. Safety monitoring of calcium and estimated glomerular filtration rate was performed, and adherence and clinical status were measured.

Results

25(OH)D concentrations

SUBMITTER: Schwartz JB 

PROVIDER: S-EPMC4724876 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature