Genotype and phylogenetic characterization of hepatitis B virus among multi-ethnic cohort in Hawaii.

ABSTRACT:

Aim

Hepatitis B virus (HBV) genomes in carriers from Hawaii have not been evaluated previously. The aim of the present study was to evaluate the distribution of HBV genotypes and their clinical relevance in Hawaii.

Methods

Genotyping of HBV among 61 multi-ethnic carriers in Hawaii was performed by genetic methods. Three complete genomes and 61 core promoter/precore regions of HBV were sequenced directly.

Results

HBV genotype distribution among the 61 carriers was 23.0% for genotype A, 14.7% for genotype B and 62.3% for genotype C. Genotypes A, B and C were obtained from the carriers whose ethnicities were Filipino and Caucasian, Southeast Asian, and various Asian and Micronesian, respectively. All cases of genotype B were composed of recombinant strains with genotype

SUBMITTER: Sakurai M 

PROVIDER: S-EPMC4724971 | biostudies-literature | 2004 Aug

REPOSITORIES: biostudies-literature