Early detection of cardiac dysfunction in the type 1 diabetic heart using speckle-tracking based strain imaging.

ABSTRACT: Enhanced sensitivity in echocardiographic analyses may allow for early detection of changes in cardiac function beyond the detection limits of conventional echocardiographic analyses, particularly in a small animal model. The goal of this study was to compare conventional echocardiographic measurements and speckle-tracking based strain imaging analyses in a small animal model of type 1 diabetes mellitus. Conventional analyses revealed differences in ejection fraction, fractional shortening, cardiac output, and stroke volume in diabetic animals relative to controls at 6-weeks post-diabetic onset. In contrast, when assessing short- and long-axis speckle-tracking based strain analyses, diabetic mice showed changes in average systolic radial strain, radial strain rate, radial displacement, and

SUBMITTER: Shepherd DL 

PROVIDER: S-EPMC4725063 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature