The apical complex protein Pals1 is required to maintain cerebellar progenitor cells in a proliferative state.

ABSTRACT: Through their biased localization and function within the cell, polarity complex proteins are necessary to establish the cellular asymmetry required for tissue organization. Well-characterized germinal zones, mitogenic signals and cell types make the cerebellum an excellent model for addressing the crucial function of polarity complex proteins in the generation and organization of neural tissues. Deletion of the apical polarity complex protein Pals1 in the developing cerebellum results in a remarkably undersized cerebellum with disrupted layers in poorly formed folia and strikingly reduced granule cell production. We demonstrate that Pals1 is not only essential for cerebellum organogenesis, but also for preventing premature differentiation and thus maintaining progenitor pools in cerebella

SUBMITTER: Park JY 

PROVIDER: S-EPMC4725200 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature