DNA methylation is critical for tooth agenesis: implications for sporadic non-syndromic anodontia and hypodontia.

ABSTRACT: Hypodontia is caused by interactions among genetic, epigenetic, and environmental factors during tooth development, but the actual mechanism is unknown. DNA methylation now appears to play a significant role in abnormal developments, flawed phenotypes, and acquired diseases. Methylated DNA immunoprecipitation (MeDIP) has been developed as a new method of scanning large-scale DNA-methylation profiles within particular regions or in the entire genome. Here, we performed a genome-wide scan of paired DNA samples obtained from 4 patients lacking two mandibular incisors and 4 healthy controls with normal dentition. We scanned another female with non-syndromic anodontia and her younger brother with the same gene mutations of the PAX9,MSX1,AXIN2 and EDA, but without developmental abnormalities in

SUBMITTER: Wang J 

PROVIDER: S-EPMC4725352 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature