SDPR functions as a metastasis suppressor in breast cancer by promoting apoptosis.

ABSTRACT: Metastatic dissemination of breast cancer cells represents a significant clinical obstacle to curative therapy. The loss of function of metastasis suppressor genes is a major rate-limiting step in breast cancer progression that prevents the formation of new colonies at distal sites. However, the discovery of new metastasis suppressor genes in breast cancer using genomic efforts has been slow, potentially due to their primary regulation by epigenetic mechanisms. Here, we report the use of model cell lines with the same genetic lineage for the identification of a novel metastasis suppressor gene, serum deprivation response (SDPR), localized to 2q32-33, a region reported to be associated with significant loss of heterozygosity in breast cancer. In silico metaanalysis of publicly available gen

SUBMITTER: Ozturk S 

PROVIDER: S-EPMC4725521 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature