Phenotypic Association Analyses With Copy Number Variation in Recurrent Depressive Disorder.

ABSTRACT:

Background

Defining the molecular genomic basis of the likelihood of developing depressive disorder is a considerable challenge. We previously associated rare, exonic deletion copy number variants (CNV) with recurrent depressive disorder (RDD). Sex chromosome abnormalities also have been observed to co-occur with RDD.

Methods

In this reanalysis of our RDD dataset (N = 3106 cases; 459 screened control samples and 2699 population control samples), we further investigated the role of larger CNVs and chromosomal abnormalities in RDD and performed association analyses with clinical data derived from this dataset.

Results

We found an enrichment of Turner's syndrome among cases of depression compared with the frequency observed in a large population sample (N = 34,910) of li

SUBMITTER: Rucker JJ 

PROVIDER: S-EPMC4725574 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature