Longitudinal studies of a B cell-derived signature of tolerance in renal transplant recipients.

ABSTRACT: Biomarkers of transplant tolerance would enhance the safety and feasibility of clinical tolerance trials and potentially facilitate management of patients receiving immunosuppression. To this end, we examined blood from spontaneously tolerant renal transplant recipients and patients enrolled in two interventional tolerance trials using flow cytometry and gene expression profiling. Using a previously reported tolerant cohort as well as newly identified tolerant patients, we confirmed our previous finding that tolerance was associated with increased expression of B cell-associated genes relative to immunosuppressed patients. This was not accounted for merely by an increase in total B cell numbers, but was associated with the increased frequencies of transitional and naïve B cells. Moreover,

SUBMITTER: Newell KA 

PROVIDER: S-EPMC4725587 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature