Adiposity throughout adulthood and risk of sudden cardiac death in women.

ABSTRACT:

Background

Sudden cardiac death (SCD) is often the first manifestation of coronary heart disease (CHD) among women. Data regarding BMI and risk of SCD are limited and conflicting.

Objectives

We examined the association of BMI repeatedly measured over 32 years and BMI during early and mid-adulthood with risk of SCD in the Nurses' Health Study.

Methods

We prospectively followed 72,484 women free of chronic disease from 1980-2012. We ascertained adult height, current weight, and weight at age 18 at baseline and updated weight biennially. The primary endpoint was SCD (n=445).

Results

When updated biennially, higher BMI was associated with greater SCD risk after adjusting for confounders (p, linear trend: <0.001). Compared to a BMI of 21.0-22.9, the multivariate RR

SUBMITTER: Chiuve SE 

PROVIDER: S-EPMC4725590 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature