Effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in healthy Chinese volunteers.

ABSTRACT:

Purpose

To investigate the effects of probenecid and cimetidine on the pharmacokinetics of nemonoxacin in humans.

Methods

Two independent, open-label, randomized, crossover studies were conducted in 24 (12 per study) healthy Chinese volunteers. In Study 1, each volunteer received a single oral dose of 500 mg of nemonoxacin alone or with 1.5 g of probenecid divided into three doses within 25 hours. In Study 2, each volunteer received a single oral dose of 500 mg of nemonoxacin alone or with multiple doses of cimetidine (400 mg thrice daily for 7 days). The plasma and urine nemonoxacin concentrations were determined using validated liquid chromatography-tandem mass spectrometry methods.

Results

Coadministration of nemonoxacin with probenecid reduced the renal clearance

SUBMITTER: Zhang YF 

PROVIDER: S-EPMC4725632 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature