A Signaling Lipid Associated with Alzheimer's Disease Promotes Mitochondrial Dysfunction.

ABSTRACT: Fundamental changes in the composition and distribution of lipids within the brain are believed to contribute to the cognitive decline associated with Alzheimer's disease (AD). The mechanisms by which these changes in lipid composition affect cellular function and ultimately cognition are not well understood. Although "candidate gene" approaches can provide insight into the effects of dysregulated lipid metabolism they require a preexisting understanding of the molecular targets of individual lipid species. In this report we combine unbiased gene expression profiling with a genome-wide chemogenomic screen to identify the mitochondria as an important downstream target of PC(O-16:0/2:0), a neurotoxic lipid species elevated in AD. Further examination revealed that PC(O-16:0/2:0) similarly pro

SUBMITTER: Kennedy MA 

PROVIDER: S-EPMC4725818 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature