Architecture and Function of Mechanosensitive Membrane Protein Lattices.

ABSTRACT: Experiments have revealed that membrane proteins can form two-dimensional clusters with regular translational and orientational protein arrangements, which may allow cells to modulate protein function. However, the physical mechanisms yielding supramolecular organization and collective function of membrane proteins remain largely unknown. Here we show that bilayer-mediated elastic interactions between membrane proteins can yield regular and distinctive lattice architectures of protein clusters, and may provide a link between lattice architecture and lattice function. Using the mechanosensitive channel of large conductance (MscL) as a model system, we obtain relations between the shape of MscL and the supramolecular architecture of MscL lattices. We predict that the tetrameric and pentameri

SUBMITTER: Kahraman O 

PROVIDER: S-EPMC4725903 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature