Endothelial cell dysfunction and cardiac hypertrophy in the STOX1 model of preeclampsia.

ABSTRACT: Preeclampsia is a disease of pregnancy involving systemic endothelial dysfunction. However, cardiovascular consequences of preeclampsia are difficult to analyze in humans. The objective of the present study is to evaluate the cardiovascular dysfunction induced by preeclampsia by examining the endothelium of mice suffering of severe preeclampsia induced by STOX1 overexpression. Using Next Generation Sequencing on endothelial cells of mice carrying either transgenic or control embryos, we discovered significant alterations of gene networks involved in inflammation, cell cycle, and cardiac hypertrophy. In addition, the heart of the preeclamptic mice revealed cardiac hypertrophy associated with histological anomalies. Bioinformatics comparison of the networks of modified genes in the endotheli

SUBMITTER: Ducat A 

PROVIDER: S-EPMC4725931 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature