Structural Elucidation of a Carnosine-Acrolein Adduct and its Quantification in Human Urine Samples.

ABSTRACT: Aldehydes accumulate in inflammation, during myocardial infarction and have been associated with pain symptoms. One pathway of aldehyde detoxification is the conjugation with carnosine. A 3-methylpyridinium carnosine adduct from the reaction of carnosine and acrolein was characterized using extensive spectroscopic measurements. The adduct with urinary concentrations of 1.82 ± 0.68 nmol/mg of creatinine is one of the most abundant acrolein metabolites in urine and opens promising therapeutic strategies for carnosine.

SUBMITTER: Bispo VS 

PROVIDER: S-EPMC4726056 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature