A network analysis of cofactor-protein interactions for analyzing associations between human nutrition and diseases.

ABSTRACT: The involvement of vitamins and other micronutrients in intermediary metabolism was elucidated in the mid 1900's at the level of individual biochemical reactions. Biochemical pathways remain the foundational knowledgebase for understanding how micronutrient adequacy modulates health in all life stages. Current daily recommended intakes were usually established on the basis of the association of a single nutrient to a single, most sensitive adverse effect and thus neglect interdependent and pleiotropic effects of micronutrients on biological systems. Hence, the understanding of the impact of overt or sub-clinical nutrient deficiencies on biological processes remains incomplete. Developing a more complete view of the role of micronutrients and their metabolic products in protein-mediated rea

SUBMITTER: Scott-Boyer MP 

PROVIDER: S-EPMC4726080 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature