Prediction and characterization of protein-protein interaction network in Bacillus licheniformis WX-02.

ABSTRACT: In this study, we constructed a protein-protein interaction (PPI) network of B. licheniformis strain WX-02 with interolog method and domain-based method, which contained 15,864 edges and 2,448 nodes. Although computationally predicted networks have relatively low coverage and high false-positive rate, our prediction was confirmed from three perspectives: local structural features, functional similarities and transcriptional correlations. Further analysis of the COG heat map showed that protein interactions in B. licheniformis WX-02 mainly occurred in the same functional categories. By incorporating the transcriptome data, we found that the topological properties of the PPI network were robust under normal and high salt conditions. In addition, 267 different protein complexes were identifie

SUBMITTER: Han YC 

PROVIDER: S-EPMC4726086 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature