Imaging and radiation effects of gold nanoparticles in tumour cells.

ABSTRACT: Gold nanoparticle radiosensitization represents a novel technique in enhancement of ionising radiation dose and its effect on biological systems. Variation between theoretical predictions and experimental measurement is significant enough that the mechanism leading to an increase in cell killing and DNA damage is still not clear. We present the first experimental results that take into account both the measured biodistribution of gold nanoparticles at the cellular level and the range of the product electrons responsible for energy deposition. Combining synchrotron-generated monoenergetic X-rays, intracellular gold particle imaging and DNA damage assays, has enabled a DNA damage model to be generated that includes the production of intermediate electrons. We can therefore show for the first

SUBMITTER: McQuaid HN 

PROVIDER: S-EPMC4726169 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature