Analysis of spatial-temporal gene expression patterns reveals dynamics and regionalization in developing mouse brain.

ABSTRACT: Allen Brain Atlas (ABA) provides a valuable resource of spatial/temporal gene expressions in mammalian brains. Despite rich information extracted from this database, current analyses suffer from several limitations. First, most studies are either gene-centric or region-centric, thus are inadequate to capture the superposition of multiple spatial-temporal patterns. Second, standard tools of expression analysis such as matrix factorization can capture those patterns but do not explicitly incorporate spatial dependency. To overcome those limitations, we proposed a computational method to detect recurrent patterns in the spatial-temporal gene expression data of developing mouse brains. We demonstrated that regional distinction in brain development could be revealed by localized gene expression

SUBMITTER: Chou SJ 

PROVIDER: S-EPMC4726224 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature