Temperature effect on the chemomechanical regulation of substeps within the power stroke of a single Myosin II.

ABSTRACT: Myosin IIs in the skeletal muscle are highly efficient nanoscale machines evolved in nature. Understanding how they function can not only bring insights into various biological processes but also provide guidelines to engineer synthetic nanoscale motors working in the vicinity of thermal noise. Though it was clearly demonstrated that the behavior of a skeletal muscle fiber, or that of a single myosin was strongly affected by the temperature, how exactly the temperature affects the kinetics of a single myosin is not fully understood. By adapting the newly developed transitional state model, which successfully explained the intriguing motor force regulation during skeletal muscle contraction, here we systematically explain how exactly the power stroke of a single myosin proceeds, with the co

SUBMITTER: Dong C 

PROVIDER: S-EPMC4726395 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature