Socs36E Controls Niche Competition by Repressing MAPK Signaling in the Drosophila Testis.

ABSTRACT: The Drosophila testis is a well-established system for studying stem cell self-renewal and competition. In this tissue, the niche supports two stem cell populations, germ line stem cells (GSCs), which give rise to sperm, and somatic stem cells called cyst stem cells (CySCs), which support GSCs and their descendants. It has been established that CySCs compete with each other and with GSCs for niche access, and mutations have been identified that confer increased competitiveness to CySCs, resulting in the mutant stem cell and its descendants outcompeting wild type resident stem cells. Socs36E, which encodes a negative feedback inhibitor of the JAK/STAT pathway, was the first identified regulator of niche competition. The competitive behavior of Socs36E mutant CySCs was attributed to increase

SUBMITTER: Amoyel M 

PROVIDER: S-EPMC4726490 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature