Comparative Study of Injury Models for Studying Muscle Regeneration in Mice.

ABSTRACT:

Background

A longstanding goal in regenerative medicine is to reconstitute functional tissues or organs after injury or disease. Attention has focused on the identification and relative contribution of tissue specific stem cells to the regeneration process. Relatively little is known about how the physiological process is regulated by other tissue constituents. Numerous injury models are used to investigate tissue regeneration, however, these models are often poorly understood. Specifically, for skeletal muscle regeneration several models are reported in the literature, yet the relative impact on muscle physiology and the distinct cells types have not been extensively characterised.

Methods

We have used transgenic Tg:Pax7nGFP and Flk1GFP/+ mouse models to respectively count

SUBMITTER: Hardy D 

PROVIDER: S-EPMC4726569 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature