Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases.

ABSTRACT: Radionecrosis is a well-characterized effect of stereotactic radiosurgery (SRS) and is occasionally associated with serious neurologic sequelae. Here, we investigated the incidence of and clinical variables associated with the development of radionecrosis and related radiographic changes after SRS for brain metastases in a cohort of patients with long-term follow up. 271 brain metastases treated with single-fraction linear accelerator-based SRS were analyzed. Radionecrosis was diagnosed either pathologically or radiographically. Univariate and multivariate Cox regression was performed to determine the association between radionecrosis and clinical factors available prior to treatment planning. After median follow up of 17.2 months, radionecrosis was observed in 70 (25.8%) lesions, includin

SUBMITTER: Kohutek ZA 

PROVIDER: S-EPMC4726630 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature